Sleep Drives Metabolite Clearance from the Adult Brain 이라는 제목의 논문이 최근에 출판되었습니다.
치매를 예방하려면 잠을 충분히 잘 자야할 것 같습니다.
The conservation of sleep across all animal species suggests that sleep serves a vital function.
We here report that sleep has a critical function in ensuring metabolic homeostasis. Using
real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice,
we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial
space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial
fluid. In turn, convective fluxes of interstitial fluid increased the rate of b-amyloid clearance
during sleep. Thus, the restorative function of sleep may be a consequence of the enhanced
removal of potentially neurotoxic waste products that accumulate in the awake central nervous
system.
