Partipetting

Partipetting

We propose a novel handling technique of chemical substances termed ‘partipetting’, which allows the one-step pipetting of various chemical-laden hydrogels. We pipette and assemble various types of encoded chemical-laden microparticles in microwell arrays in parallel. The combination of this heterogeneous particle chip and a cell chip induces the release of the chemicals from the hydrogels and, eventually, the chemicals treat the targets.

Liquid-capped Particle

We propose a novel drug screening platform based on a our new concept of liquid handling method called ‘partipetting’, which enable whole drug screening with a single pipetting process. To demonstrate our concept of liquid handling, we present a generation of liquid capped microsphere particles, heterogeneous assembly of different liquid capped particles, breaking and releasing of these liquid capped microshell particles. 

Optofluidic Maskless Lithography(OFML)

Optofluidic maskless lithography is a technique that can synthesize free-floating microstructures in microfluidic channels at the desired time and location within the field of view of the lithography system. By uniquely combining the concept of maskless and continuous-flow lithography techniques in the microfluidic channels, we experimentally demonstrate real-time control of the in-situ polymerization process to dynamically synthesize extruded polymeric microstructures with various two-dimensional shapes. 

Color-barcoded Microparticle

We propose vivid, free-floating structural coloured particles with multi-axis rotational control using a colour-tunable magnetic material and a new printing method. Our colour-barcoded magnetic microparticles offer a coding capacity easily into the billions with distinct magnetic handling capabilities including active positioning for code readouts and active stirring for improved reaction kinetics in microscale environments. A DNA hybridization assay is done using the colour-barcoded magnetic microparticles to demonstrate multiplexing capabilities. 

Railed Microfluidics

“Railed microfluidics,” is a fully deterministic way of guiding microstructures inside a fluidic channel. Using railed microfluidics, we achieved fluidic self assembly of various complex heterogeneous microstructures. By transporting many different microstructures to exact assembly sites, complex 1D and 2D systems are assembled without wasting a single microstructure.